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- Title
Gender differences among treatment-seeking adults with cannabis use disorder: Clinical profiles of women and men enrolled in the achieving cannabis cessation-evaluating N-acetylcysteine treatment (ACCENT) study.
- Authors
Sherman, Brian J.; McRae‐Clark, Aimee L.; Baker, Nathaniel L.; Sonne, Susan C.; Killeen, Therese K.; Cloud, Kasie; Gray, Kevin M.
- Abstract
<bold>Background and Objectives: </bold>Recent evidence suggests that women may fare worse than men in cannabis trials with pharmacologic interventions. Identifying baseline clinical profiles of treatment-seeking cannabis-dependent adults could inform gender-specific treatment planning and development.<bold>Methods: </bold>The current study compared baseline demographic, cannabis use, and psychiatric factors between women (n = 86) and men (n = 216) entering the Achieving Cannabis Cessation-Evaluating N-acetylcysteine Treatment (ACCENT) study, a multi-site, randomized controlled trial conducted within the National Drug Abuse Treatment Clinical Trials Network.<bold>Results: </bold>Women reported greater withdrawal intensity (p = .001) and negative impact of withdrawal (p = .001), predominantly due to physiological and mood symptoms. Women were more likely to have lifetime panic disorder (p = .038) and current agoraphobia (p = .022), and reported more days of poor physical health (p = .006) and cannabis-related medical problems (p = .023). Women reporting chronic pain had greater mean pain scores than men with chronic pain (p = .006). Men and women did not differ on any measures of baseline cannabis use.<bold>Discussion and Conclusions: </bold>Cannabis-dependent women may present for treatment with more severe and impairing withdrawal symptoms and psychiatric conditions compared to cannabis-dependent men. This might help explain recent evidence suggesting that women fare worse than men in cannabis treatment trials of pharmacologic interventions. Baseline clinical profiles of treatment-seeking adults can inform gender-specific treatment planning and development.<bold>Scientific Significance: </bold>Cannabis-dependent women may benefit from integrated treatment focusing on co-occurring psychiatric disorders and targeted treatment of cannabis withdrawal syndrome.(Am J Addict 2017;26:136-144).
- Subjects
MARIJUANA abuse; GENDER differences (Psychology); MENTAL illness risk factors; CHRONIC pain; DRUG withdrawal symptoms; PATIENTS; PSYCHIATRIC epidemiology; SUBSTANCE abuse &; psychology; COMPARATIVE studies; HYDROCARBONS; RESEARCH methodology; MEDICAL care; MEDICAL cooperation; RESEARCH; RESEARCH funding; SEX distribution; SUBSTANCE abuse; COMORBIDITY; EVALUATION research; PATIENTS' attitudes; FREE radical scavengers; ACETYLCYSTEINE; PREVENTION; DIAGNOSIS
- Publication
American Journal on Addictions, 2017, Vol 26, Issue 2, p136
- ISSN
1055-0496
- Publication type
journal article
- DOI
10.1111/ajad.12503