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- Title
Increased Urine IgMand IgG2 Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.
- Authors
Torffvit, Ole; Kalani, Majid; Apelqvist, Jan; Eliasson, Björn; Eriksson, JanW.; Brismar, Kerstin; Jörneskog, Gun
- Abstract
Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG2 were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgMand IgG2 indicate decreased glomerular size selectivity. Urine IgMlevels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG2 despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG2 might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.
- Subjects
IMMUNOGLOBULIN M; IMMUNOGLOBULIN G; DALTEPARIN (Drug); PEOPLE with diabetes; TYPE 2 diabetes treatment; DIABETIC foot; GLOMERULAR filtration rate
- Publication
Biotechnology Research International, 2012, p1
- ISSN
2090-3138
- Publication type
Article
- DOI
10.1155/2012/480529