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- Title
Evaluation of the Diagnostic Utility of Selected Serum Adipokines and Cytokines in Subjects with MASLD—A Pilot Study.
- Authors
Zyśk, Beata; Ostrowska, Lucyna; Smarkusz-Zarzecka, Joanna; Orywal, Karolina; Mroczko, Barbara; Cwalina, Urszula
- Abstract
Excess adipose tissue, particularly of the visceral type, triggering chronic low-grade inflammation and altering its secretory profile, is a contributing factor to the initiation and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to compare the levels of selected adipokines and cytokines in individuals with normal weight and obesity, assessing their potential for diagnosing MASLD and establishing a cutoff point for body fat content associated with hepatic steatosis development. The research involved 99 participants categorized by body mass index and MASLD presence, undergoing body composition analysis, liver elastography, biochemical tests, and evaluation of adipokines and cytokines in serum. The results indicated elevated IL-6 (interleukin 6) serum levels in individuals with obesity with MASLD compared to the normal-weight group without MASLD. The multivariate regression analysis demonstrated a connection between hepatic steatosis and total adipose tissue content, VAT (visceral adipose tissue), VAT/SAT (subcutaneous adipose tissue) ratio, HOMA-IR (homeostasis model assessment of insulin resistance), IL-6, Il-1β (interleukin 1β), and MMP-2 (matrix metalloproteinase 2). Among the adipokines and cytokines examined in this study, interleukin 6 was the strongest predictor of MASLD regardless of gender. In addition, an association between the development of hepatic steatosis and higher serum IL-1β levels and higher adipose tissue was observed in women. However, further studies on a larger group of patients are needed to consider the use of these cytokines as markers of MASLD. The HOMA-IR index demonstrated potential diagnostic utility in identifying hepatic steatosis.
- Subjects
NON-alcoholic fatty liver disease; METABOLIC disorders; ADIPOKINES; RISK assessment; ADIPOSE tissues; BODY mass index; RECEIVER operating characteristic curves; RESEARCH funding; SCIENTIFIC observation; PILOT projects; BODY composition; KRUSKAL-Wallis Test; MULTIVARIATE analysis; DESCRIPTIVE statistics; MATRIX metalloproteinases; ANALYSIS of variance; CYTOKINES; DATA analysis software; CONFIDENCE intervals; OBESITY; INTERLEUKINS; REGRESSION analysis; DISEASE risk factors; DISEASE complications
- Publication
Nutrients, 2024, Vol 16, Issue 9, p1381
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16091381