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- Title
Whole-Grain Highland Barley Attenuates Atherosclerosis Associated with NLRP3 Inflammasome Pathway and Gut Microbiota in ApoE −/− Mice.
- Authors
Wu, Tong; Yu, Qinye; Luo, Yingting; Dai, Zijian; Zhang, Yuhong; Wang, Chao; Shen, Qun; Xue, Yong
- Abstract
The efficacy and mechanism of highland barley in the treatment of atherosclerosis have received little attention. Herein, we aimed to explore whether highland barley supplementation can prevent atherosclerosis progression and improve gut microbiota disorder in apolipoprotein E knockout (ApoE−/−) mice. Male ApoE−/− mice were fed a high-fat diet with whole-grain highland barley (WHB) or refined highland barley for 18 weeks. WHB substantially inhibited the formation of atherosclerotic plaques, reduced serum tumor necrosis factor-α, and downregulated the expression of NLRP3 in the aorta. Furthermore, the 16S rRNA analysis revealed that highland barley supplementation helped to restore the dysregulation of the gut microbiota, as evidenced by an increase in the relative abundance of specific beneficial bacteria known for their anti-inflammatory properties, such as Lachnospiraceae, Lactobacillus, Muribaculaceae, and Bifidobacterium. Highland barley supplementation might alleviate atherosclerotic plaque formation by modulating the NLRP3 inflammasome pathway and the synthesis of anti-inflammatory metabolites by the gut microbiota.
- Subjects
RNA analysis; DISEASE progression; CYTOKINES; INTERLEUKINS; STATISTICS; TRIGLYCERIDES; HDL cholesterol; SEQUENCE analysis; GUT microbiome; ANIMAL experimentation; SERUM; ANTI-inflammatory agents; ONE-way analysis of variance; SIGNAL peptides; LDL cholesterol; DIETARY supplements; ATHEROSCLEROSIS; CELLULAR signal transduction; GENE expression; TUMOR necrosis factors; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; RESEARCH funding; AORTA; POLYMERASE chain reaction; DATA analysis software; DATA analysis; BARLEY; MICE; METABOLITES; LIPIDS; CHOLESTEROL; PHARMACODYNAMICS
- Publication
Nutrients, 2023, Vol 15, Issue 19, p4186
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15194186