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- Title
Does Pizza Consumption Favor an Improved Disease Activity in Rheumatoid Arthritis?
- Authors
De Vito, Roberta; Parpinel, Maria; Speciani, Michela Carola; Fiori, Federica; Bianco, Rachele; Caporali, Roberto; Ingegnoli, Francesca; Scotti, Isabella; Schioppo, Tommaso; Ubiali, Tania; Cutolo, Maurizio; Grosso, Giuseppe; Ferraroni, Monica; Edefonti, Valeria
- Abstract
To our knowledge, no studies so far have investigated the role of pizza and its ingredients in modulating disease activity in rheumatoid arthritis (RA). We assessed this question via a recent cross-sectional study including 365 participants from Italy, the birthplace of pizza. Multiple robust linear and logistic regression models were fitted with the tertile consumption categories of each available pizza-related food item/group (i.e., pizza, refined grains, mozzarella cheese, and olive oil) as independent variables, and each available RA activity measure (i.e., the Disease Activity Score on 28 joints with C-reactive protein (DAS28-CRP), and the Simplified Disease Activity Index (SDAI)) as the dependent variable. Stratified analyses were carried out according to the disease severity or duration. Participants eating half a pizza >1 time/week (vs. ≤2 times/month) reported beneficial effects on disease activity, with the significant reductions of ~70% (overall analysis), and 80% (the more severe stratum), and the significant beta coefficients of −0.70 for the DAS28-CRP, and −3.6 for the SDAI (overall analysis) and of −1.10 and −5.30 (in long-standing and more severe RA, respectively). Among the pizza-related food items/groups, mozzarella cheese and olive oil showed beneficial effects, especially in the more severe stratum. Future cohort studies are needed to confirm this beneficial effect of pizza and related food items/groups on RA disease activity.
- Subjects
ITALY; THERAPEUTIC use of olive oil; C-reactive protein; CONVENIENCE foods; CHEESE; FOOD consumption; CROSS-sectional method; REGRESSION analysis; SEVERITY of illness index; RHEUMATOID arthritis; DISEASE duration; DESCRIPTIVE statistics; RESEARCH funding; GRAIN; LOGISTIC regression analysis; DISEASE management
- Publication
Nutrients, 2023, Vol 15, Issue 15, p3449
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15153449