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- Title
Effects of Whey Protein Isolate on Body Composition, Muscle Mass, and Strength of Chronic Heart Failure Patients: A Randomized Clinical Trial.
- Authors
dos Santos, Elisa M.; Moreira, Annie S. B.; Huguenin, Grazielle V. B.; Tibiriça, Eduardo; De Lorenzo, Andrea
- Abstract
Heart failure (HF) is associated with a reduction of skeletal muscle mass. Whey protein isolate (WPI) has been beneficial in increasing muscle mass and strength, in addition to improving body composition. The goal of this research was to evaluate the effect of WPI on the body composition, muscle mass, and strength of chronic HF patients. For this purpose, twenty-five patients of both genders with predominantly NYHA I functional class and a median age of 65.5 (60.5–71.0) years were used to conduct a randomized, single-blind, placebo-controlled clinical trial and received 30 g per day of WPI for 12 weeks. Anthropometric measurements, body composition analysis, and biochemical exams were performed at the beginning and end of the study. An increase in skeletal muscle mass was observed in the intervention group after 12 weeks. A reduction in waist circumference, body fat percentage, and an increase in skeletal muscle index was observed when compared to the placebo group. No significant effect on muscle strength was observed after 12 weeks of intervention. These data demonstrate that WPI consumption contributed to the increase of skeletal muscle mass, strength, and reduction of body fat in HF patients.
- Subjects
SKELETAL muscle physiology; BODY composition; GRIP strength; CONFIDENCE intervals; CHRONIC diseases; ANTHROPOMETRY; MANN Whitney U Test; DIETARY supplements; RANDOMIZED controlled trials; T-test (Statistics); MUSCLE strength; DESCRIPTIVE statistics; CHI-squared test; WHEY proteins; DATA analysis software; HEART failure; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 10, p2320
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15102320