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- Title
B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study.
- Authors
Merle, Bénédicte M. J.; Barthes, Stéphanie; Féart, Catherine; Cougnard-Grégoire, Audrey; Korobelnik, Jean-François; Rougier, Marie-Bénédicte; Delyfer, Marie-Noëlle; Delcourt, Cécile
- Abstract
B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (≥10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25–0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53–0.99], p = 0.049; HR, 0.90 [0.81–0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD.
- Subjects
FRANCE; RETINAL degeneration; CONFIDENCE intervals; VITAMIN B deficiency; VITAMIN B complex; DIETARY supplements; DESCRIPTIVE statistics; FOLIC acid; LONGITUDINAL method; PROPORTIONAL hazards models; DISEASE risk factors; OLD age
- Publication
Nutrients, 2022, Vol 14, Issue 14, pN.PAG
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14142821