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- Title
N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the Fat-1 Mouse Model.
- Authors
Lecques, Jessica-Dominique; Kerr, Brynna J. K.; Hillyer, Lyn M.; Kang, Jing X.; Robinson, Lindsay E.; Ma, David W. L.
- Abstract
Concussions and mild traumatic brain injury (m-TBI) have been identified as a consequential public health concern because of their potential to cause considerable impairments in physical, cognitive, behavioral, and social functions. Given their prominent structural and functional roles in the brain, n-3 polyunsaturated fatty acids (PUFA) have been identified as a potentially viable prophylactic agent that may ameliorate the deleterious effects of m-TBI on brain function. The purpose of the present pilot study was to investigate the effect of n-3 PUFA on neurologic function using a weight drop injury (WDI) model. Fat-1 mice, capable of synthesizing n-3 PUFA endogenously from n-6 PUFA, and their wild-type (WT) counterparts, were subjected to a mild low-impact WDI on the closed cranium, and recovery was evaluated using the neurological severity score (NSS) to assess the motor and neurobehavioral outcomes. In comparison to the WT mice, the fat-1 mice had a significantly (p ≤ 0.05) lower NSS at all time points post-WDI, and significantly greater neurological restoration measured as the time to first movement. Overall, these findings demonstrate the protective effect of n-3 PUFA against mild brain injury.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; PILOT projects; BODY weight; ANIMAL experimentation; CONVALESCENCE; TIME; SEVERITY of illness index; NEUROLOGIC manifestations of general diseases; COMPARATIVE studies; OMEGA-3 fatty acids; BRAIN injuries; MICE
- Publication
Nutrients, 2021, Vol 13, Issue 11, p4092
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13114092