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- Title
Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results.
- Authors
Bowman, Gene L.; Silbert, Lisa C.; Dodge, Hiroko H.; Lahna, David; Hagen, Kirsten; Murchison, Charles F.; Howieson, Diane; Kaye, Jeffrey; Quinn, Joseph F.; Shinto, Lynne
- Abstract
Vascular risk factors for age-related cognitive decline are significant, and their management may ultimately prove the most successful strategy for reducing risk and sustaining cognitive health. This randomized, double-blinded, placebo-controlled trial with parallel group allocation to either marine n-3 polyunsaturated fatty acids (n-3 PUFA) or soybean oil placebo assesses the effects on the total volume of accumulation in cerebral white matter hyperintensities (WMH), a potentially modifiable neurovascular component of age-related cognitive decline. Total WMH accumulation over 3 years is the primary endpoint. The safety and efficacy of n-3 PUFA is evaluated in older adults with significant WMH and suboptimum plasma n-3 PUFA as inclusion criteria. One hundred and two non-demented older adults were enrolled with a mean age of 81.1 (±4.4) years, WMH of 19.4 (±16.1) cm3, and a plasma n-3 PUFA of 86.64 (±29.21) µg/mL. 61% were female, 28% were apolipoprotein E epsilon 4 carriers, and the mean mini-mental state exam (MMSE) was 27.9 (±1.7). This trial provides an initial evaluation of n-3 PUFA effects on WMH, a reproducible and valid risk biomarker for cognitive decline, as well as on inflammatory biomarkers thought to play a role in WMH accumulation. We present the baseline results and operational experience of enriching a study population on advanced age, blood n-3 PUFA, and magnetic resonance imaging (MRI) derived WMH with biomarker outcomes (WMH, inflammation markers) in a dementia prevention paradigm.
- Subjects
THERAPEUTIC use of omega-3 fatty acids; INFLAMMATION prevention; BIOMARKERS; COGNITION disorders; MAGNETIC resonance imaging; NEURORADIOLOGY; STATISTICAL sampling; SOY oil; UNSATURATED fatty acids; RANDOMIZED controlled trials; TREATMENT effectiveness; DESCRIPTIVE statistics; CEREBRAL small vessel diseases; WHITE matter (Nerve tissue); OLD age
- Publication
Nutrients, 2019, Vol 11, Issue 4, p735
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11040735