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- Title
Inflammatory Dietary Pattern, IL-17F Genetic Variant, and the Risk of Colorectal Cancer.
- Authors
Cho, Young Ae; Lee, Jeonghee; Kim, Jeongseon; Oh, Jae Hwan; Chang, Hee Jin; Sohn, Dae Kyung; Shin, Aesun
- Abstract
A proinflammatory diet may increase the risk of colorectal cancer, but its role may differ according to individuals’ genetic variants. We aimed to examine whether a specific dietary pattern reflecting inflammation was associated with a risk of colorectal cancer and whether <italic>IL-17F</italic> genetic variant altered this association. In a study of 695 colorectal cancer cases and 1846 controls, we derived a reduced rank regression dietary pattern using 32 food groups as predictors and the plasma C-reactive protein (CRP) concentration as the response. High CRP levels were associated with a high risk of colorectal cancer (OR (95% CI) = 3.58 (2.65–4.82) for the highest quartile vs. lowest quartile). After adjusting for potential confounding factors, high pattern scores were associated with a high risk of colorectal cancer (OR (95% CI) = 9.98 (6.81–14.62) for the highest quartile vs. lowest quartile). When stratified by the <italic>IL-17F</italic> rs763780 genotype, this association was stronger for individuals carrying the C allele (<italic>p</italic> for interaction = 0.034), particularly for individuals with rectal cancer (<italic>p</italic> for interaction = 0.011). In conclusion, a dietary pattern reflecting inflammation was significantly associated with colorectal cancer risk. Moreover, this association could be modified according to the <italic>IL-17F</italic> rs763780 genotype and anatomic site.
- Subjects
COLON tumors; ALLELES; C-reactive protein; CONFIDENCE intervals; FOOD habits; GENETIC polymorphisms; INFLAMMATION; INTERLEUKINS; RECTUM tumors; REGRESSION analysis; CONFOUNDING variables; ODDS ratio; DISEASE complications; TUMOR risk factors; CANCER risk factors
- Publication
Nutrients, 2018, Vol 10, Issue 6, p724
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu10060724