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- Title
The Evolving Interplay among Abundant Adipokines in Patients with Hepatitis C during Viral Clearance.
- Authors
Tsung-Hsing Chen; Chen-Ming Hsu; Cheng-Hui Lin; Cheng-Yu Lin; Chia-Jung Kuo; Shu-Wei Huang; Chun-Wei Chen; Hao-Tsai Cheng; Chau-Ting Yeh; Cheng-Tang Chiu; Ming-Ling Chang
- Abstract
How hepatatitis C virus (HCV) infection affects the interplay among abundant adipokines in the host remains unclear. A prospective study was conducted with 450 consecutive genotype 1 (G1) and G2 HCV patients who completed a course of anti-HCV therapy and underwent pre-therapy and 24-week post-therapy surveys to assess various profiles and levels of abundant adipokines, including leptin, adiponectin, and plasminogen activator inhibitor-1 (PAI-1). Before anti-HCV therapy, multivariate analyses showed gender to be associated with leptin and adiponectin levels, and BMI with leptin and PAI-1 levels. Among patients with a sustained virological response (SVR, n = 372), associations at 24 weeks post-therapy were as follows: gender and BMI with all adipokine levels; hepatic steatosis and aspartate aminotransferase to platelet ratio index with adiponectin levels; and HOMA-IR and HCV genotype with PAI-1 levels. Paired t-tests revealed increased post-therapeutic PAI-1 levels in G1 SVR patients and decreased adiponectin levels in all SVR patients compared to pre-therapeutic levels. HCV infection may obscure associations between abundant adipokines and metabolic/hepatic profiles. In SVR patients, a higher hierarchical status of PAI-1 versus adiponectin in affecting glucose metabolism was noted at 24 weeks post-therapy. Such genotype-non-specific adiponectin decreases and G1-specific PAI-1 increases warrant careful follow-up of HCV patients after SVR according to viral genotype.
- Publication
Nutrients, 2017, Vol 9, Issue 6, p570
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu9060570