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- Title
Effects of amoxicillin and metronidazole as an adjunct to scaling and root planing on glycemic control in patients with periodontitis and type 2 diabetes: A short‐term randomized controlled trial.
- Authors
Xu, Xinran; Lu, He; Huo, Pengcheng; Jin, Dongsiqi; Zhu, Yunxuan; Meng, Huanxin
- Abstract
Objective: To assess the effects of amoxicillin and metronidazole with scaling and root planing (SRP) on periodontal parameters and glycemic control in patients with severe periodontitis and diabetes mellitus. Background: Adjunctive antibiotics use is advantageous for treating periodontitis in patients with severe periodontitis and diabetes. However, the effects of adjunctive antibiotic use on hemoglobin A1c (HbA1c) levels remain unclear. Methods: This short‐term, randomized controlled trial enrolled patients with severe periodontitis and type 2 diabetes. The patients were randomly allocated to SPR only (i.e., control) or SPR + antibiotics (500 mg of amoxicillin and 200 mg of metronidazole, three times daily for 7 days) groups. Periodontal and hematological parameters were assessed at baseline and 3 months after treatment. Inter‐ and intra‐group analyses were performed using Student's t‐tests, Mann–Whitney U tests, and the binary logistic regression models. p‐values of <.05 were considered statistically significant. Results: This study enrolled 49 patients, with 23 and 26 patients in the SRP‐only and SRP + antibiotics groups, respectively. The periodontal parameters improved significantly and similarly in both groups after treatment (p <.05). The SRP + antibiotics group had more sites of improvement than the SRP‐only group when the initial probing depth was >6 mm. (698 [78.96%] vs. 545 [73.35%], p =.008). The HbA1c levels decreased in the SRP‐only and SRP + antibiotics groups after treatment (0.39% and 0.53%, respectively). The multivariable binary logistic regression model demonstrated that antibiotics administration and a high baseline HbA1c level were associated with a greater reduction in the HbA1c level (odds ratio = 4.551, 95% confidence interval: 1.012–20.463; odds ratio = 7.162, 95% confidence interval: 1.359–37.753, respectively). Conclusions: SRP and SRP plus systemic antibiotics were beneficial for glycemic control. Adjunctive antibiotic use slightly improved the outcome for patients with severe periodontitis and poorly controlled diabetes.
- Subjects
DENTAL scaling; ANTIBIOTICS; T-test (Statistics); GLYCEMIC control; STATISTICAL sampling; LOGISTIC regression analysis; PROBABILITY theory; QUESTIONNAIRES; MULTIPLE regression analysis; AMOXICILLIN; TREATMENT effectiveness; MANN Whitney U Test; ODDS ratio; METRONIDAZOLE; TYPE 2 diabetes; TOOTH root planing; DRUG efficacy; CONFIDENCE intervals; PERIODONTITIS; EVALUATION
- Publication
Journal of Periodontal Research, 2024, Vol 59, Issue 2, p249
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.13225