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- Title
A practical method to diagnose muscle degradation in normonourished patients with chronic heart failure.
- Authors
Aquilani, Roberto; Opasich, Cristina; Gualco, Alessandra; Baiardi, Paola; Pasini, Evasio; Testa, Amidio; Viglio, Simona; Iadarola, Paolo; Verri, Manuela; D'Agostino, Luca; Boschi, Federica
- Abstract
Background & Aim of the study The goal of this study was to investigate muscle protein degradation (MPD) and find possible biohumoral indicator of MPD in patients with chronic heart failure (CHF). Plasma 3-methylhistidine concentration (3MEH) could be high in clinically stable CHF with normal renal function and blood urea levels (BU) could be a proxy of 3MEH in clinical environments. Methods In 38 outpatients with stable CHF (30 males and 8 females; 56.4±10.6 yrs) and 17 healthy subjects (13 males and 4 females) we determined 3MEH, BU and creatinine (CR) concentrations in peripheral venous blood. The tests were made at 8 am, after a meat-free diet on the previous day. Results Compared to controls, patients had higher concentrations of plasma 3MEH (9.5±4.8 vs 3.7±1.1 μmol/L; p<0.001) blood BU (45.65±2 vs 29.88±2.38 mg/dl; p<0.001) serum CR (1.043±0.02 vs 0.892±0.03; p=0.002). Moreover, 3MEH was positively correlated with BU (r=+0.49; p<0.001), resting VO2/Kg (n=24, r=+0.48; p=0.02), NYHA functional class (r=+0.32; p<0.05) in the studied patients. It was found that with a BU threshold of 38mg/dl, BU can predict 3MEH levels higher than 6μmol/L with 68% probability. Conclusions The study showed a high prevalence of MPD in stable CHF. BU can positively predict MPD in 70% of patients.
- Subjects
CHRONIC diseases; FLUOROSIS; HEART failure; CONGESTIVE heart failure; UREA; CREATININE; HETEROCYCLIC compounds; BLOOD plasma; SERUM
- Publication
Archives: The International Journal of Medicine, 2009, Vol 2, Issue 2, p226
- ISSN
1791-4000
- Publication type
Article