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- Title
Myocardial triglyceride content at 3 T cardiovascular magnetic resonance and left ventricular systolic function: a cross-sectional study in patients hospitalized with acute heart failure.
- Authors
Pen-An Liao; Gigin Lin; Shang-Yueh Tsai; Chao-Hung Wang; Yu-Hsiang Juan; Yu-Ching Lin; Ming-Ting Wu; Lan-Yan Yang; Min-Hui Liu; Tsun-Ching Chang; Yu-Chun Lin; Yu-Chieh Huang; Pei-Ching Huang; Jiun-Jie Wang; Shu-Hang Ng; Koon-Kwan Ng
- Abstract
Background: Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic resonance spectroscopy (¹H-MRS) and left ventricular (LV) function assessed on cardiovascular magnetic resonance (CMR) in patients who were hospitalized with HF. Methods: A total of 50 patients who were discharged after hospitalization for acute HF and 21 age- and sex- matched controls were included in the study. Myocardial TG content and LV parameters (function and mass) were measured on a 3.0 T MR scanner. Fatty acid (FA) and unsaturated fatty acid (UFA) content was normalized against water (W) using the LC-Model algorithm. The patient population was dichotomized according to the left ventricular ejection fraction (LVEF, <50 % or ≥ 50 %). Results: H-MRS data were available for 48 patients and 21 controls. Of the 48 patients, 25 had a LVEF <50 % (mean, 31.2 %), whereas the remaining 23 had a normal LVEF (mean, 60.2 %). Myocardial UFA/W ratio was found to differ significantly in patients with low LVEF, normal LVEF, and controls (0.79 % vs. 0.21 % vs. 0.14 %, respectively, = 0.02). p The myocardial UFA/TG ratio was associated with LV mass ( = 0.39, < 0.001) and modestly related to LV end-diastolic r p volume (LVEDV; = 0.24, = 0.039). We also identified negative correlations of the myocardial FA/TG ratio with both LV r p mass ( = -0.39, < 0.001) and LVEDV ( = -0.24, = 0.039). r p r p Conclusions: As compared with controls, patients who were discharged after hospitalization for acute HF had increased myocardial UFA content; furthermore, UFA was inversely related with LVEF, LV mass and, to a lesser extent, LVEDV. Our study may stimulate further research on the measure of myocardial UFA content by ¹H-MRS for outcome prediction. Trial registration: ClinicalTrial.gov: NCT02378402. Registered 27/02/2015
- Subjects
ANALYSIS of variance; HEART; HEART failure; MAGNETIC resonance imaging; RESEARCH funding; STATISTICS; TRIGLYCERIDES; CROSS-sectional method; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test; ONE-way analysis of variance
- Publication
Journal of Cardiovascular Magnetic Resonance (BioMed Central), 2016, p1
- ISSN
1532-429X
- Publication type
Article
- DOI
10.1186/s12968-016-0228-3