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- Title
Synthesis of Chiral β-Aminomalonates from 2-Chlorotetrafluoroethanesulfinyl Aldimines through the Mannich Reaction.
- Authors
Yang, Kai; Jiang, Min; Liu, Jin‐Tao
- Abstract
An efficient method for the synthesis of chiral β-aminomalonates in good yields and with high diastereoselectivities was achieved through Mannich reactions between 2-chlorotetrafluoroethanesulfinyl aldimines and dialkyl malonates in the presence of N-trimethylsilylimidazole. Further transformation of the products gave the corresponding β-lactams in good yields and with high optical purities.
- Subjects
ORGANIC synthesis; MALONATES; STEREOSELECTIVE reactions; MANNICH reaction; ALDIMINES; LACTAMS
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 14, p3109
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500134