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- Title
2-Nitroglycals: Versatile Building Blocks for the Synthesis of 2-Aminoglycosides.
- Authors
Delaunay, Thierry; Poisson, Thomas; Jubault, Philippe; Pannecoucke, Xavier
- Abstract
2-Deoxy-2-amino-substituted glycosides are ubiquitous compounds in biochemistry and biology. Therefore, the development of new synthetic pathways to access natural and non-natural derivatives is highly desirable. In that context, 2-nitroglycals appeared as versatile building blocks for reaching those targets. Since their first introduction almost forty years ago, their synthetic utility has been widely demonstrated and they have been used to access natural and non-natural compounds with potent biological activity. The aim of this review is to summarize the developed routes to these versatile intermediates as well as their reactivity. The main applications of the chemistry developed with 2-nitroglycal derivatives is also highlighted in this first review.
- Subjects
AMINOGLYCOSIDES; ORGANIC synthesis; CARBOHYDRATE synthesis; GLYCOSIDE synthesis; ORGANIC chemistry
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 34, p7525
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402805