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- Title
Synthesis of Epibatidine Analogues Having a 2-Substituted 2-Azabicyclo[2.2.2]octane Skeleton.
- Authors
Wauters, Iris; De Blieck, Ann; Muylaert, Koen; Heugebaert, Thomas S. A.; Stevens, Christian V.
- Abstract
The synthesis of 1-cyano-2-aza-[2.2.2]bicyclooctanes has been studied using the dynamic cyanide addition to cyclohexanone derivatives. These compounds were further elaborated into a new class of epibatidine derivatives from which a number of examples were fully deprotected to give the potentially active compounds. The highly hydrophilic character of the compounds resulted in a difficult isolation and purification of the epibatidine analogues.
- Subjects
CYCLOOCTANES; ORGANIC synthesis; CYCLOALKANES; CYCLOHEXANONES; PAIN management
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 6, p1296
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301397