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- Title
What is your diagnosis? Perifemoral mass in a cow.
- Authors
Bisby, Tricia M.; Pratt, Suzanne M.; Kent Fenton, R.; Nickie Baird, A.; Thompson, Craig A.; Lin, Tsang L.
- Abstract
A 15-year-old female Simmental cross-breed cow was presented to the Purdue University Veterinary Teaching Hospital for evaluation of a perifemoral soft tissue mass. Impression smears made from an excisional biopsy contained a population of pleomorphic mesenchymal cells with abundant, periodic acid–Schiff-positive (PAS), intracytoplasmic granular material, and rare elongated multinucleated cells consistent with strap-like cells. A second population of small round cells suggestive of lymphocytes or progenitor cells was also noted. A cytologic diagnosis of sarcoma was made, with rhabdomyosarcoma considered most likely based on the large amount of PAS-positive material (presumed to be glycogen) and the rare strap-like cells. Histopathologic sections contained an unencapsulated, densely cellular neoplasm composed of haphazardly arranged highly pleomorphic mesenchymal cells and a few small round cells. The mesenchymal cells were positive for vimentin, non-specific muscle actin, and myoglobin, and negative for phosphotungstic acid-hematoxylin, smooth muscle actin, and desmin. Glycogen granules were confirmed by transmission electron microscopy. A diagnosis of pleomorphic rhabdomyosarcoma was made. While cytologic findings may suggest rhabdomyosarcoma, cytologic features can be highly variable, and a definitive diagnosis usually requires cytochemical and immunohistochemical staining.
- Subjects
SIMMENTAL cattle; CATTLE breeding; VETERINARY colleges; GRANULAR materials; LYMPHOCYTES; SARCOMA
- Publication
Veterinary Clinical Pathology, 2009, Vol 38, Issue 3, p343
- ISSN
0275-6382
- Publication type
Article
- DOI
10.1111/j.1939-165X.2009.00118.x