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- Title
Expression of Ki-67 and MDM2 at the Tumour Invasive Front in Oral Squamous Cell Carcinoma: Relationship with Clinicopathologic Factors.
- Authors
Lee, C. N.; Zain, R. B.; Abidin, N. Z.; Khoo, S. P.; Kumar, S. K. S.
- Abstract
Background: The tumour invasive front of oral squamous cell carcinoma (OSCC) has been recognized to harbour better prognostic information. The general aim of this study was to evaluate the biological activity using proliferative marker, Ki-67 and an apoptotic marker, MDM2 at the invasive front of oral squamous cell carcinoma. Methods: A total of 31 OSCC cases from the buccal mucosa were evaluated with specific antibodies to Ki-67 and MDM2 using immunohistochemistry (IHC). The sociodemographic and clinicopathological parameters were recorded and analysed against the IHC findings. Results: The expression of Ki-67 and MDM2 were detected in 90.3% (28) and 64.5% (20) of the cases respectively. The present study found significant association between MDM2 expression with gender (P=0.026) and Broder's tumour grading (P=0.041). Significant association was also observed between combined Ki-67/MDM2 expression with both gender (P=0.011) and Broders' tumour grading (P=0.031). The present study found no significant association between Ki-67 and MDM2 at the tumour invasive front. No association was also found between Ki-67 expression as a proliferative marker (using labelling index) and MDM2 as an apoptotic markers. Conclusions: The tumour invasive front may be suitable for evaluating the expression of Ki-67 as their localization is seen at the basal and parabasal areas. The value of evaluating MDM2 at the tumour invasive front is still controversial as this study showed that the localization of MDM2 is at the suprabasal and the upper region. Such MDM2 distribution is in accordance to some reports but contrary to another report in the literature.
- Subjects
TUMOR markers; BIOMARKERS; SQUAMOUS cell carcinoma; CANCER; IMMUNOHISTOCHEMISTRY
- Publication
Malaysian Dental Journal, 2005, Vol 26, Issue 2, p72
- ISSN
0126-8023
- Publication type
Article