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- Title
Acoustic Activation Imaging With Intravenous Perfluoropropane Nanodroplets Results in Selective Bioactivation of the Risk Area.
- Authors
Li, Shouqiang; Chen, Cheng; Lof, John; Stolze, Elizabeth A.; Sklenar, Jiri; Chen, Xucai; Pacella, John J.; Villanueva, Flordeliza S.; Matsunaga, Terry O.; Everbach, E. Carr; Radio, Stanley J.; Westphal, Sherry N.; Shiva, Sruti; Xie, Feng; Leng, Xiaoping; Porter, Thomas R.
- Abstract
Background: Acoustically activatable perfluoropropane droplets (PD) can be formulated from commercially available microbubble preparations. Diagnostic transthoracic ultrasound frequencies have resulted in acoustic activation (AA) predominately within myocardial infarct zones (IZ). Objective: We hypothesized that the AA area following acute coronary ischemia/reperfusion (I/R) would selectively enhance the developing scar zone, and target bioeffects specifically to this region. Methods: We administered intravenous PD in 36 rats and 20 pigs at various stages of myocardial scar formation (30 minutes, 1 day, and 7 days post I/R) to determine what effect infarct age had on the AA within the IZ. This was correlated with histology, myeloperoxidase activity, and tissue nitrite activity. Results: The degree of AA within the IZ in rats was not associated with collagen content, neutrophil infiltration, or infarct age. AA within 24 hours of I/R was associated with increased nitric oxide utilization selectively within the IZ (P <.05 compared with remote zone). The spatial extent of AA in pigs correlated with infarct size only when performed before sacrifice at 7 days (r =.74, P <.01). Conclusions: Acoustic activation of intravenous PD enhances the developing scar zone following I/R, and results in selective tissue nitric oxide utilization.
- Subjects
MYOCARDIAL infarction; DIAGNOSTIC ultrasonic imaging; NITRIC oxide; MYELOPEROXIDASE; ACOUSTIC imaging; MYOCARDIAL ischemia
- Publication
Journal of Ultrasound in Medicine, 2024, Vol 43, Issue 6, p1063
- ISSN
0278-4297
- Publication type
Article
- DOI
10.1002/jum.16435