We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Predictors of paravalvular aortic regurgitation after surgery for Behcet's disease-related severe aortic regurgitation.
- Authors
Choi, Hong-Mi; Kim, Hyung-Kwan; Park, Sung-Ji; Lee, Hyun-Jung; Yoon, Yeonyee E.; Park, Jun-Bean; Kim, Yong-Jin; Cho, Goo-Young; Hwang, In-Chang; Sohn, Dae-Won; Oh, Jae K.
- Abstract
<bold>Background: </bold>Behcet's disease (BD)-related aortic regurgitation (AR) is known to be associated with paravalvular leakage (PVL) after successful aortic valve (AV) surgery. This study aimed to determine predictors of PVL after successful AV surgery in BD patients. We retrospectively collected data of 35 patients (42.1 ± 9.1 years, 27 men) who underwent surgery for severe BD-related AR at two tertiary centers. The diagnosis was established based on echocardiographic, surgical, and/or pathological findings in conjunction with the International Study Group criteria for BD. A total of 76 cases of AV surgery in 35 patients were analyzed.<bold>Results: </bold>A median follow-up duration was 8.0 years (interquartile range, 5.4-14.3 years). PVL developed in 18 patients (51.4%) within 2 years after the first surgery. Six patients who met the diagnostic criteria for BD did not develop PVL, in whom 5 patients took immunosuppressive therapy (IST). However, 4 of 9 patients (44.4%) who did not meet the diagnostic criteria developed PVL, in whom four (44.4%) patients took IST. On multivariable analysis, postoperative IST and concomitant aortic root replacement (ARR) were two independent predictors for less PVL development (HR 0.38, 95% CI 0.17-0.89, p = 0.025 for postoperative IST; HR 0.17, 95% CI 0.08-0.36, p < 0.001 for concomitant ARR). Preoperative IST use did not determine PVL development (p = 0.75).<bold>Conclusions: </bold>Postoperative, but not preoperative, IST and concomitant ARR were independent predictors of less development of PVL. Special attention is required for early diagnosis BD-related AR, especially in patients not satisfying the current diagnostic criteria.
- Subjects
AORTIC valve insufficiency; BIOPROSTHESIS; AORTIC valve surgery; AORTIC valve; SURGERY; ECHOCARDIOGRAPHY; BEHCET'S disease; RETROSPECTIVE studies; TREATMENT effectiveness; KAPLAN-Meier estimator; PROPORTIONAL hazards models
- Publication
Orphanet Journal of Rare Diseases, 2019, Vol 14, Issue 1, pN.PAG
- ISSN
1750-1172
- Publication type
journal article
- DOI
10.1186/s13023-019-1083-8