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- Title
Lymph node micrometastases are associated with disease recurrence and poor survival for early-stage non-small cell lung cancer patients: a meta-analysis.
- Authors
Xu Feng Deng; Li Jiang; Quan Xing Liu; Dong Zhou; Bing Hou; Kefan Cui; Jia Xin Min; Ji Gang Dai; Deng, Xu Feng; Jiang, Li; Liu, Quan Xing; Zhou, Dong; Hou, Bing; Cui, Kefan; Min, Jia Xin; Dai, Ji Gang
- Abstract
<bold>Background: </bold>We performed a meta-analysis to clarify whether the molecular detection of tumor cells or micrometastases in the lymph node (LN) indicates a high risk of disease recurrence and poor survival in negative pathologic lymph node status non-small cell lung cancer (NSCLC).<bold>Methods: </bold>A literature search was performed using relevant keywords. We searched relevant studies from PubMed, Embase, and the Cochrane Library. Direct and indirect meta-estimates were generated using Review Manager software with fixed effects for the study. Study-to-study heterogeneity was summarized using I (2) statistics and predictive intervals (PIs).<bold>Results: </bold>Our analysis of eight eligible studies revealed that patients with lymph node micrometastases (LNMM) were associated with poor overall survival (OS) (HR, 1.98; 95 % CI, 1.50 to 2.62; p < 0.00001) and disease-free survival (DFS) (HR, 2.34; 95 % CI, 1.67-3.27; p < 0.00001).<bold>Conclusion: </bold>LNMM is associated with an increased risk of disease recurrence and poor survival in patients with negative pathologic node negative NSCLC. Thus, these patients need to be carefully followed up after the initial pulmonary resection.
- Subjects
LYMPH nodes; META-analysis; NON-small-cell lung carcinoma; DISEASE relapse; DISEASE risk factors; MICROMETASTASIS; COMPARATIVE studies; LUNG cancer; LUNG tumors; RESEARCH methodology; MEDICAL cooperation; METASTASIS; PROGNOSIS; RESEARCH; SURVIVAL analysis (Biometry); EVALUATION research; DIAGNOSIS
- Publication
Journal of Cardiothoracic Surgery, 2016, Vol 11, p1
- ISSN
1749-8090
- Publication type
journal article
- DOI
10.1186/s13019-016-0427-x