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- Title
Kimura's disease: effects of age on clinical presentation.
- Authors
Kakehi, E; Kotani, K; Otsuka, Y; Fukuyasu, Y; Hashimoto, Y; Sakurai, S; Hirotani, A; Simizu, K; Fujita, R; Shoji, K; Adachi, S; Matsumura, M
- Abstract
Background Kimura's disease (KD) is known to be dominant among young Asian men, but it can also occur in middle- and advanced-aged people. The clinical characteristics of KD, especially by age, are not well known. Aim This study was performed to investigate the effects of age on the clinical characteristics of KD. Design We conducted a case series study. Methods All case studies of patients diagnosed with KD were collected via a PubMed search of studies published until August 2018. The data were analyzed by age group. Results In total, 215 studies were reviewed (238 patients; mean age of 36 years). The male:female ratio was 4:1 overall, 17:1 in patients aged <20 years, 4:1 in patients aged 20–39 years and 2:1 in patients aged ≥40 years (P = 0.01). The percentage of patients with pruritus was 15.4% overall, 3.8% in patients aged <20 years, 15.5% in patients aged 20–39 years and 21.7% in patients aged ≥40 years (P = 0.02). The time to diagnosis was 5.3 years overall, 3.2 years in patients aged <20 years, 4.7 years in patients aged 20–39 years and 7.1 years in patients aged ≥40 years (P < 0.01). Conclusions The proportion of female patients affected the incidence of pruritus, and the time to diagnosis increased as the patients' age increased. There were no significant age-related differences in region/race, complications, multiplicity, laterality, anatomical distribution, maximum size, eosinophil count, immunoglobulin E level, initial treatment, recurrence or outcomes. This may be useful information for the diagnosis of KD.
- Subjects
AGE factors in disease; IMMUNOGLOBULIN E; ASIANS; AGE groups; KIMURA disease
- Publication
QJM: An International Journal of Medicine, 2020, Vol 113, Issue 5, p336
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcz312