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- Title
Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS.
- Authors
Jinsil Park; Liu, Ben; Tao Chen; Hong Li; Xuemei Hu; Jing Gao; Ying Zhu; Qiang Zhu; Boqin Qiang; Jiangang Yuan; Xiaozhong Peng; Mengsheng Qiu
- Abstract
Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2-5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.
- Subjects
CELL adhesion molecules; BIOMOLECULES; AXONS; MYELINATION; CENTRAL nervous system; NEUROSCIENCES
- Publication
Journal of Neuroscience, 2008, Vol 28, Issue 48, p12815
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2665-08.2008