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- Title
α2 Integrin +807 Polymorphism in Drug-induced Gingival Overgrowth.
- Authors
Ogino, M.; Kido, J.; Bando, M.; Hayashi, N.; Wada, C.; Nagata, T.; Nishimura, F.; Soga, Y.; Takashiba, S.; Kubota, T.; Itagaki, M.; Shimada, Y.; Tai, H.; Yoshie, H.; Yamazaki, N.; Shinohara, Y.; Kataoka, M.
- Abstract
α2 integrin on fibroblasts is reported to play an important role in the induction of drug-induced gingival overgrowth, which is characterized by excessive accumulation of type I collagen in gingival connective tissue. Silent polymorphism 807 T/C within the α2 integrin gene is associated with high/low α2 integrin expression. The aim of this study was to test the hypothesis that expression of α2 integrin 807 T/C polymorphism correlates with drug-induced gingival overgrowth. A case-control study comparing 136 subjects taking calcium channel blockers (72 with vs. 64 without drug-induced gingival overgrowth) demonstrated that the frequency of the +807 C allele was significantly higher in the case group than in the controls (odds ratio, 3.61; 95% confidence interval, 2.14 - 6.10; P < 0.05). The present findings suggest that the α2 +807 C allele is one of the genetic risk factors for drug-induced gingival overgrowth.
- Subjects
GENETIC polymorphisms; GINGIVAL hyperplasia; GINGIVA; INTEGRINS; PHAGOCYTOSIS; IMMUNE response
- Publication
Journal of Dental Research, 2005, Vol 84, Issue 12, p1183
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/154405910508401217