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- Title
Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection.
- Authors
Carey, Maureen; Arju, Tuhinur; Cotton, James A; Alam, Masud; Kabir, Mamun; Faruque, Abu S G; Haque, Rashidul; Petri, William A; Gilchrist, Carol A
- Abstract
Cryptosporidium species are a major cause of diarrhea and associated with growth failure. There is currently only limited knowledge of the parasite's genomic variability. We report a genomic analysis of Cryptosporidium parvum isolated from Bangladeshi infants and reanalysis of sequences from the United Kingdom. Human isolates from both locations shared 154 variants not present in the cattle-derived reference genome, suggesting host-specific adaptation of the parasite. Remarkably 34.6% of single-nucleotide polymorphisms unique to human isolates were nonsynonymous and 8.2% of these were in secreted proteins. Linkage disequilibrium decay indicated frequent recombination. The genetic diversity of C. parvum has potential implications for vaccine and therapeutic design. Clinical Trials Registration. NCT02764918.
- Subjects
BANGLADESH; UNITED Kingdom; CRYPTOSPORIDIUM; CRYPTOSPORIDIUM parvum; HUMAN biology; CLINICAL trial registries; GENOMICS; LINKAGE disequilibrium
- Publication
Journal of Infectious Diseases, 2023, Vol 228, Issue 9, p1292
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad257