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- Title
Contribution of Staphylococcal Enterotoxin B to Staphylococcus aureus Systemic Infection.
- Authors
Bae, Justin S; Da, Fei; Liu, Ryan; He, Lei; Lv, Huiying; Fisher, Emilie L; Rajagopalan, Govindarajan; Li, Min; Cheung, Gordon Y C; Otto, Michael
- Abstract
Staphylococcal enterotoxin B (SEB), which is produced by the major human pathogen, Staphylococcus aureus, represents a powerful superantigenic toxin and is considered a bioweapon. However, the contribution of SEB to S. aureus pathogenesis has never been directly demonstrated with genetically defined mutants in clinically relevant strains. Many isolates of the predominant Asian community-associated methicillin-resistant S. aureus lineage sequence type (ST) 59 harbor seb, implying a significant role of SEB in the observed hypervirulence of this lineage. We created an isogenic seb mutant in a representative ST59 isolate and assessed its virulence potential in mouse infection models. We detected a significant contribution of seb to systemic ST59 infection that was associated with a cytokine storm. Our results directly demonstrate that seb contributes to S. aureus pathogenesis, suggesting the value of including SEB as a target in multipronged antistaphylococcal drug development strategies. Furthermore, they indicate that seb contributes to fatal exacerbation of community-associated methicillin-resistant S. aureus infection.
- Subjects
STAPHYLOCOCCUS aureus infections; ENTEROTOXINS; CYTOKINE release syndrome; LABORATORY mice; STAPHYLOCOCCUS aureus; RESEARCH; ANIMAL experimentation; RESEARCH methodology; METHICILLIN-resistant staphylococcus aureus; MEDICAL cooperation; EVALUATION research; STAPHYLOCOCCAL diseases; COMPARATIVE studies; MICROBIAL virulence; TOXINS; MICE
- Publication
Journal of Infectious Diseases, 2021, Vol 223, Issue 10, p1766
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa584