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- Title
Design, synthesis and pharmacophoric model building of new 3-alkoxymethyl/3-phenyl indole-2-carboxamides with potential antiproliferative activity.
- Authors
Abdelrahman, Mostafa H.; Aboraia, Ahmed S.; Youssif, Bahaa G. M.; Elsadek, Bakheet E. M.
- Abstract
Novel 3-alkoxymethyl/3-phenyl indole-2-carboxamide derivatives were synthesized and evaluated for their anticancer activity. Most of the tested compounds showed moderate to excellent activity against the tested cell lines ( MCF7 and HCT116). 3-Phenyl substitution on indole with p-piperidinyl phenethyl 24a and p-dimethylamino phenethyl 24c exhibited anticancer activity against MCF7 with IC50 of 0.13 and 0.14 μ m, respectively. Further mechanistic study of the most active compounds through their action on cell cycle showed disturbance in cell cycle progression and cell cycle arrest. For future development of this series of compounds, pharmacophore study was conducted which indicated that the enhancement of the activity could be achieved through the addition of acceptor or donating groups to the already-present indole nucleus.
- Subjects
ANTINEOPLASTIC agents; CELL cycle; INDOLE; CARBOXAMIDES; PHENETHYLAMINES; CANCER
- Publication
Chemical Biology & Drug Design, 2017, Vol 90, Issue 1, p64
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/cbdd.12928