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- Title
Pharmacogenetics and response to ß-adrenergic receptor antagonists in heart failure.
- Authors
Muszkat, Mordechai; Stein, C. Michael
- Abstract
The article discusses the effects of pharmacogenetics and the response to ß-adrenergic receptor(ß-AR) antagonists to treat patients with congestive heart failure (CHF). Several clinical factors such as age and severity of left ventricular dysfunction have contributed to the ability of an individual patient to tolerate a ß-blocker. Furthermore, the treatment was associated with an increase in myocardial ß-AR density and improved hemodynamic responses.
- Subjects
CONGESTIVE heart failure; HEART failure; BETA adrenoceptors; PHARMACOGENOMICS; BIOCHEMICAL genetics; MEDICAL genetics
- Publication
Clinical Pharmacology & Therapeutics, 2005, Vol 77, Issue 3, p123
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1016/j.clpt.2004.10.007