OpenURL Connection Search

Select item for more details and to access through your institution.

Critical importance of correctly defining and reporting secondary endpoints when assessing the ethics of research biopsies.
Published in:
Clinical Trials, 2024, v. 21, n. 5, p. 650, doi. 10.1177/17407745241244753
By:
- Levit, Laura A;
- Garrett-Mayer, Elizabeth;
- Peppercorn, Jeffrey;
- Ratain, Mark J
Publication type:
Article
Creating and evaluating genetic tests predictive of drug response.
Published in:
2008
By:
- Weiss, Scott T.;
- McLeod, Howard L.;
- Flockhart, David A.;
- Dolan, M. Eileen;
- Benowitz, Neal L.;
- Johnson, Julie A.;
- Ratain, Mark J.;
- Giacomini, Kathleen M.
Publication type:
review
Phase I study of adozelesin administered by 24-hour continuous intravenous infusion.
Published in:
JNCI: Journal of the National Cancer Institute, 1994, v. 86, n. 5, p. 368, doi. 10.1093/jnci/86.5.368
By:
- Fleming, Gini F.;
- Ratain, Mark J.
Publication type:
Article
Statistical and Ethical Issues in the Design and Conduct of Phase I and II Clinical Trials of New Anticancer Agents.
Published in:
JNCI: Journal of the National Cancer Institute, 1993, v. 85, n. 20, p. 1637
By:
- Ratain, Mark J.;
- Mick, Rosemarie;
- Schilsky, Richard L.;
- Siegler, Mark
Publication type:
Article
Phase I trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study.
Published in:
1993
By:
- Lichtman, Stuart M.;
- Ratain, Mark J.;
- Van Echo, David A.;
- Rosner, Gary;
- Egorin, Merrill J.;
- Budman, Daniel R.;
- Vogelzang, Nicholas J.;
- Norton, Larry;
- Schilsky, Richard L.;
- Lichtman, S M;
- Ratain, M J;
- Van Echo, D A;
- Rosner, G;
- Egorin, M J;
- Budman, D R;
- Vogelzang, N J;
- Norton, L;
- Schilsky, R L
Publication type:
journal article
Model-guided determination of maximum tolerated dose in phase I clinical trials: evidence for increased precision.
Published in:
1993
By:
- Mick, Rosemarie;
- Ratain, Mark J.;
- Mick, R;
- Ratain, M J
Publication type:
journal article
Phase I–II Trial of Erythropoietin in the Treatment of Cisplatin-Associated Anemia.
Published in:
JNCI: Journal of the National Cancer Institute, 1992, v. 84, n. 2, p. 98
By:
- Miller, Carole B.;
- Platanias, Leonidas C.;
- Mills, Sharon R.;
- Zahurak, Marianna L.;
- Ratain, Mark J.;
- Ettinger, David S.;
- Jones, Richard J.
Publication type:
Article
Modeling Interpatient Pharmacodynamic Variability of Etoposide.
Published in:
JNCI: Journal of the National Cancer Institute, 1991, v. 83, n. 21, p. 1560
By:
- Mick, Rosemarie;
- Ratain, Mark J.
Publication type:
Article
BOOK REVIEWS.
Published in:
JNCI: Journal of the National Cancer Institute, 1990, v. 82, n. 20, p. 1644
By:
- RATAIN, MARK J.
Publication type:
Article
Clinical Pharmacokinetics of High-Dose Leucovorin Calcium After Intravenous and Oral Administration.
Published in:
JNCI: Journal of the National Cancer Institute, 1990, v. 82, n. 17, p. 1411
By:
- Schilsky, Richard L.;
- Ratain, Mark J.
Publication type:
Article
Response.
Published in:
JNCI: Journal of the National Cancer Institute, 1989, v. 81, n. 19, p. 1510
By:
- RATAIN, MARK J.;
- SCHILSKY, RICHARD L.
Publication type:
Article
Low-Dose Interferon Alfa-2b in the Treatment of Hairy Cell Leukemia.
Published in:
JNCI: Journal of the National Cancer Institute, 1989, v. 81, n. 15, p. 1172
By:
- Moormeier, Jill A.;
- Ratain, Mark J.;
- Westbrook, Carol A.;
- Vardiman, James W.;
- Daly, Karen M.;
- Golomb, Harvey M.
Publication type:
Article
Hydroxyurea and Etoposide: In Vitro Synergy and Phase I Clinical Trial2.
Published in:
JNCI: Journal of the National Cancer Institute, 1988, v. 80, n. 17, p. 1412, doi. 10.1093/jnci/80.17.1412
By:
- Ratain, Mark J.;
- Schilsky, Richard L.;
- Wojack, Bette R.;
- Simon, Todd;
- Senekjian, Elizabeth K.;
- Vogelzang, Nicholas J.
Publication type:
Article
Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients.
Published in:
Journal of Personalized Medicine, 2021, v. 11, n. 12, p. 1343, doi. 10.3390/jpm11121343
By:
- Saulsberry, Loren;
- Danahey, Keith;
- Middlestadt, Merisa;
- O'Leary, Kevin J.;
- Nutescu, Edith A.;
- Chen, Thomas;
- Lee, James C.;
- Ruhnke, Gregory W.;
- George, David;
- House, Larry;
- van Wijk, Xander M. R.;
- Yeo, Kiang-Teck J.;
- Choksi, Anish;
- Hartman, Seth W.;
- Knoebel, Randall W.;
- Friedman, Paula N.;
- Rasmussen, Luke V.;
- Ratain, Mark J.;
- Perera, Minoli A.;
- Meltzer, David O.
Publication type:
Article
Subcutaneous Atezolizumab: A Jab Without a Benefit.
Published in:
Clinical Pharmacology in Drug Development, 2022, v. 11, n. 1, p. 134, doi. 10.1002/cpdd.1061
By:
- Peer, Cody J.;
- Zimmerman, Sara M.;
- Figg, William D.;
- Goldstein, Daniel A.;
- Ratain, Mark J.
Publication type:
Article
Gazing into a crystal ball?cancer therapy in the post-genomic era.
Published in:
Nature Medicine, 2001, v. 7, n. 3, p. 283, doi. 10.1038/85414
By:
- Ratain, Mark J.;
- Relling, Mary V.
Publication type:
Article
Creation of a pharmacogenomics patient portal complementary to an existing institutional provider-facing clinical decision support system.
Published in:
JAMIA Open, 2021, v. 4, n. 3, p. 1, doi. 10.1093/jamiaopen/ooab067
By:
- Lipschultz, Elizabeth;
- Danahey, Keith;
- Truong, Tien M.;
- Schierer, Emily;
- Volchenboum, Samuel L.;
- Ratain, Mark J.;
- O'Donnell, Peter H.
Publication type:
Article
A survey of the population genetic variation in the human kinome.
Published in:
Journal of Human Genetics, 2009, v. 54, n. 8, p. 488, doi. 10.1038/jhg.2009.72
By:
- Wei Zhang;
- Catenacci, Daniel V. T.;
- Shiwei Duan;
- Ratain, Mark J.
Publication type:
Article
Adoption of a clinical pharmacogenomics implementation program during outpatient care-initial results of the University of Chicago '1,200 Patients Project'.
Published in:
American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, 2014, v. 166C, n. 1, p. 68, doi. 10.1002/ajmg.c.31385
By:
- O'Donnell, Peter H.;
- Danahey, Keith;
- Jacobs, Michael;
- Wadhwa, Nisha R.;
- Yuen, Shennin;
- Bush, Angela;
- Sacro, Yasmin;
- Sorrentino, Matthew J.;
- Siegler, Mark;
- Harper, William;
- Warrick, Andrea;
- Das, Soma;
- Saner, Don;
- Corless, Christopher L.;
- Ratain, Mark J.
Publication type:
Article
LETTERS AND CORRECTIONS.
Published in:
Annals of Internal Medicine, 1985, v. 103, n. 2, p. 302
By:
- Lilienfeld, David E.;
- Edlavitch, Stanley A.;
- Arrowsmith, Janet B.;
- Milstien, Julie B.;
- Kuritsky, John H.;
- Murano, Genesio;
- Adu, D.;
- Lote, C.J.;
- Michael, J.;
- Turney, J.H.;
- McMaster, P.;
- Houston, Mark C.;
- Vogelzang, Nicholas J.;
- Ratain, Mark J.;
- Pasulka, Patrick S.;
- Bistrian, Bruce R.;
- Blackburn, George L.;
- Auwern, J.;
- Boullon, R.
Publication type:
Article
Do patent applications and Cooperative Research and Development Agreements between the National Cancer Institute and industry serve the public interest?
Published in:
Nature Biotechnology, 2023, v. 41, n. 11, p. 1517, doi. 10.1038/s41587-023-02004-2
By:
- Wesevich, Austin;
- Ratain, Mark J.
Publication type:
Article
Combination therapy patents: a new front in evergreening.
Published in:
Nature Biotechnology, 2021, v. 39, n. 12, p. 1504, doi. 10.1038/s41587-021-01137-6
By:
- Strohbehn, Garth W.;
- Kacew, Alec J.;
- Goldstein, Daniel A.;
- Feldman, Robin C.;
- Ratain, Mark J.
Publication type:
Article
Negative innovation: when patents are bad for patients.
Published in:
Nature Biotechnology, 2021, v. 39, n. 8, p. 914, doi. 10.1038/s41587-021-00999-0
By:
- Feldman, Robin C.;
- Hyman, David A.;
- Price II, W. Nicholson;
- Ratain, Mark J.
Publication type:
Article
A randomized study of inpatient versus outpatient continuous infusion chemotherapy for patients with locally advanced head and neck cancer.
Published in:
1989
By:
- Vokes, Everett E.;
- Schilsky, Richard L.;
- Choi Pharmd, Kyung E. ,;
- Magid, Dawn M.;
- Guarnieri, Carol M.;
- Whaling, Susan M.;
- Ratain, Mark J.;
- Weichselbaum, Ralph R.;
- Panje, William R.;
- Vokes, E E;
- Schilsky, R L;
- Choi, K E;
- Magid, D M;
- Guarnieri, C M;
- Whaling, S M;
- Ratain, M J;
- Weichselbaum, R R;
- Panje, W R
Publication type:
journal article
Prognostic variables in hairy cell leukemia after splenectomy as initial therapy.
Published in:
1988
By:
- Ratain, Mark J.;
- Vardiman, James W.;
- Barker, Christopher M.;
- Golomb, Harvey M.;
- Ratain, M J;
- Vardiman, J W;
- Barker, C M;
- Golomb, H M
Publication type:
journal article
Flow cytometry in hairy cell leukemia before and during interferon alfa-2b therapy.
Published in:
1987
By:
- Vokes, Everett E.;
- Bitter, Mitchell A.;
- Ratain, Mark J.;
- Prystowsky, Michael B.;
- Daly, Karen;
- Golomb, Harvey M.;
- Vokes, E E;
- Bitter, M A;
- Ratain, M J;
- Prystowsky, M B;
- Daly, K;
- Golomb, H M
Publication type:
journal article
Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study.
Published in:
Investigational New Drugs, 2022, v. 40, n. 4, p. 762, doi. 10.1007/s10637-022-01247-1
By:
- LoRusso, Patricia;
- Ratain, Mark J.;
- Doi, Toshihiko;
- Rasco, Drew W.;
- de Jonge, Maja J. A.;
- Moreno, Victor;
- Carneiro, Benedito A.;
- Devriese, Lot A.;
- Petrich, Adam;
- Modi, Dimple;
- Morgan-Lappe, Susan;
- Nuthalapati, Silpa;
- Motwani, Monica;
- Dunbar, Martin;
- Glasgow, Jaimee;
- Medeiros, Bruno C.;
- Calvo, Emiliano
Publication type:
Article
Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients.
Published in:
AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-0429-4
By:
- Karas, Spinel;
- Etheridge, Amy S.;
- Tsakalozou, Eleftheria;
- Ramírez, Jacqueline;
- Cecchin, Erika;
- van Schaik, Ron H.N.;
- Toffoli, Giuseppe;
- Ratain, Mark J.;
- Mathijssen, Ron H.J.;
- Forrest, Alan;
- Bies, Robert R.;
- Innocenti, Federico
Publication type:
Article
Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial.
Published in:
Therapeutic Advances in Medical Oncology, 2020, p. 1, doi. 10.1177/1758835920974118
By:
- Reizine, Natalie;
- Vokes, Everett E.;
- Liu, Ping;
- Truong, Tien M.;
- Nanda, Rita;
- Fleming, Gini F.;
- Catenacci, Daniel V.T.;
- Pearson, Alexander T.;
- Parsad, Sandeep;
- Danahey, Keith;
- van Wijk, Xander M. R.;
- Yeo, Kiang-Teck J.;
- Ratain, Mark J.;
- O'Donnell, Peter H.
Publication type:
Article
A Novel Fully Automated Molecular Diagnostic System (AMDS) for Colorectal Cancer Mutation Detection
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0062989
By:
- Kitano, Shiro;
- Myers, Jamie;
- Nakamura, Junko;
- Yamane, Akio;
- Yamashita, Mami;
- Nakayama, Masato;
- Tsukahara, Yusuke;
- Ushida, Hiroshi;
- Liu, Wanqing;
- Ratain, Mark J.;
- Amano, Masahiko
Publication type:
Article
Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054522
By:
- Ling-Zhi Wang;
- Ramírez, Jacqueline;
- Yeo, Winnie;
- Chan, Mei-Yi Michelle;
- Win-Lwin Thuya;
- Lau, Jie-Ying Amelia;
- Seow-Ching Wan;
- Wong, Andrea Li-Ann;
- Zee, Ying-Kiat;
- Lim, Robert;
- Soo-Chin Lee;
- Ho, Paul C.;
- Lee, How-Sung;
- Chan, Anthony;
- Ansher, Sherry;
- Ratain, Mark J.;
- Boon-Cher Goh
Publication type:
Article
Evaluation of neuropathy in patients on suramin treatment.
Published in:
1997
By:
- Soliven, Betty;
- Dhand, Upinder K.;
- Kobayashi, Ken;
- Arora, Ravinder;
- Martin, Barbara;
- Petersen, Michele V.;
- Janisch, Linda;
- Vogelzang, Nicholas J.;
- Vokes, Everett E.;
- Ratain, Mark J.;
- Soliven, B;
- Dhand, U K;
- Kobayashi, K;
- Arora, R;
- Martin, B;
- Petersen, M V;
- Janisch, L;
- Vogelzang, N J;
- Vokes, E E;
- Ratain, M J
Publication type:
journal article
Drug-metabolizing enzymes: Evidence for clinical utility of pharmacogenomic tests
Published in:
2005
By:
- Andersson, Tommy;
- Flockhart, David A.;
- Goldstein, David B.;
- Huang, Shiew-Mei;
- Kroetz, Deanna L.;
- Milos, Patrice M.;
- Ratain, Mark J.;
- Thummel, Kenneth
Publication type:
Editorial
A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital*.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 5, p. 490, doi. 10.1016/j.clpt.2004.07.016
By:
- Innocenti, Federico;
- Undevia, Samir D.;
- Ramírez, Jacqueline;
- Mani, Sridhar;
- Schilsky, Richard L.;
- Vogelzang, Nicholas J.;
- Prado, Marisol;
- Ratain, Mark J.
Publication type:
Article
'Irinogenetics' and UGT1A: from Genotypes to Haplotypes*.
Published in:
Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 6, p. 495, doi. 10.1016/j.clpt.2004.01.011
By:
- Innocenti, Federico;
- Ratain, Mark J.
Publication type:
Article
A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine*.
Published in:
Clinical Pharmacology & Therapeutics, 2003, v. 73, n. 6, p. 566, doi. 10.1016/S0009-9236(03)00053-5
By:
- Sawyer, Michael B.;
- Innocenti, Federico;
- Das, Soma;
- Cheng, Cheng;
- Ramírez, Jacqueline;
- Pantle-Fisher, Friedl H.;
- Wright, Constance;
- Badner, Judith;
- Pei, Deqing;
- Boyett, James M.;
- Cook, Edwin;
- Ratain, Mark J.
Publication type:
Article
Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide.
Published in:
Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 6, p. 638, doi. 10.1067/mcp.2002.129502
By:
- Klein, Cheri Enders;
- Gupta, Elora;
- Reid, Joel M.;
- Atherton, Pamela J.;
- Sloan, Jeff A.;
- Pitot, Henry C.;
- Ratain, Mark J.;
- Kastrissios, Helen
Publication type:
Article
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism*.
Published in:
Clinical Pharmacology & Therapeutics, 1999, v. 65, n. 5, p. 576, doi. 10.1016/S0009-9236(99)70078-0
By:
- Iyer, Lalitha;
- Hall, Diana;
- Das, Soma;
- Mortell, Melissa A.;
- Ramírez, Jacqueline;
- Kim, Sarang;
- Di Rienzo, Anna;
- Ratain, Mark J.
Publication type:
Article
Etoposide combined with interferon alfa-2b: Novel exploitation of established etoposide pharmacokinetics and pharmacodynamics*.
Published in:
Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 3, p. 349, doi. 10.1016/S0009-9236(96)80013-0
By:
- Mick, Rosemarie;
- Vokes, Everett E.;
- Lestingi, Timothy M.;
- Gray-Stern, Winifred;
- Fleming, Gini F.;
- Schilsky, Richard L.;
- Ratain, Mark J.
Publication type:
Article
A population model for the leukopenic effect of etoposide*.
Published in:
Clinical Pharmacology & Therapeutics, 1995, v. 57, n. 3, p. 325, doi. 10.1016/0009-9236(95)90158-2
By:
- Karlsson, Mats O.;
- Port, Rüdiger E.;
- Ratain, Mark J.;
- Sheiner, Lewis B.
Publication type:
Article
Bootstrap validation of pharmacodynamic models defined via stepwise linear regression.
Published in:
Clinical Pharmacology & Therapeutics, 1994, v. 56, n. 2, p. 217, doi. 10.1038/clpt.1994.126
By:
- Mick, Rosemarie;
- Ratain, Mark J
Publication type:
Article
Modulation of vinblastine resistance with cyclosporine: A phase I study.
Published in:
Clinical Pharmacology & Therapeutics, 1993, v. 54, n. 4, p. 421, doi. 10.1038/clpt.1993.169
By:
- Samuels, Brian L;
- Mick, Rosemarie;
- Vogelzang, Nicholas J;
- Williams, Stephanie F;
- Schilsky, Richard L;
- Safa, Ahmad R;
- O'brien, Sheila M;
- Ratain, Mark J
Publication type:
Article
Paradoxical relationship between acetylator phenotype and amonafide toxicity.
Published in:
Clinical Pharmacology & Therapeutics, 1991, v. 50, n. 5, p. 573, doi. 10.1038/clpt.1991.183
By:
- Ratain, Mark J;
- Mick, Rosemarie;
- Berezin, Frances;
- Janisch, Linda;
- Schilsky, Richard L;
- Williams, Stephanie F;
- Smiddy, Julie
Publication type:
Article
Pharmacokinetics and pharmacodynamics of long-term continuous-infusion doxorubicin.
Published in:
Clinical Pharmacology & Therapeutics, 1989, v. 45, n. 4, p. 340, doi. 10.1038/clpt.1989.39
By:
- Ackland, Stephen P;
- Ratain, Mark J;
- Vogelzang, Nicholas J;
- Choi, Kyung E;
- Ruane, Maureen;
- Sinkule, Joseph A
Publication type:
Article
Adaptive control of etoposide administration: Impact of interpatient pharmacodynamic variability.
Published in:
Clinical Pharmacology & Therapeutics, 1989, v. 45, n. 3, p. 226, doi. 10.1038/clpt.1989.22
By:
- Ratain, Mark J;
- Schilsky, Richard L;
- Choi, Kyung E;
- Guarnieri, Carol;
- Grimmer, Dale;
- Vogelzang, Nicholas J;
- Senekjian, Elizabeth;
- Liebner, Mary Ann
Publication type:
Article
Cancer pharmacogenomics: strategies and challenges.
Published in:
Nature Reviews Genetics, 2013, v. 14, n. 1, p. 23, doi. 10.1038/nrg3352
By:
- Wheeler, Heather E.;
- Maitland, Michael L.;
- Dolan, M. Eileen;
- Cox, Nancy J.;
- Ratain, Mark J.
Publication type:
Article
Pharmacogenomics: will the promise be fulfilled?
Published in:
2011
By:
- Altman, Russ B.;
- Kroemer, Heyo K.;
- McCarty, Catherine A.;
- Ratain, Mark J.;
- Roden, Dan
Publication type:
research
Alternative trastuzumab dosing strategies in HER2-positive early breast cancer are associated with patient out-of-pocket savings.
Published in:
NPJ Breast Cancer, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41523-022-00393-2
By:
- Hsieh, Po-Hung;
- Kacew, Alec J.;
- Dreyer, Marie;
- Serritella, Anthony V.;
- Knoebel, Randall W.;
- Strohbehn, Garth W.;
- Ratain, Mark J.
Publication type:
Article
Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.
Published in:
NPJ Genomic Medicine, 2021, v. 6, n. 1, p. 1, doi. 10.1038/s41525-021-00253-1
By:
- Saulsberry, Loren;
- Danahey, Keith;
- Borden, Brittany A.;
- Lipschultz, Elizabeth;
- Traore, Maimouna;
- Ratain, Mark J.;
- Meltzer, David O.;
- O'Donnell, Peter H.
Publication type:
Article
Response.
Published in:
2008
By:
- Karrison, Theodore;
- Maitland, Michael;
- Stadler, Walter;
- Ratain, Mark J.
Publication type:
Letter

Found: 175