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- Title
Efficacy of tacrolimus capsules in patients undergoing high-risk keratoplasty.
- Authors
Xiaorong Zhang; Jia Yao; Tengfei Ma; Haoyu Chen; Hengju Xu; Yinghui Ye; Liying Zhai
- Abstract
Purpose: To evaluate the efficacy of tacrolimus capsules in patients undergoing high-risk keratoplasty. Methods: 40 high-risk patients who underwent penetrating keratoplasty at The Third Hospital of Hebei Medical University, China between January 2016 and December 2021 were included in this study. These patients were divided into two groups based on the specific immunosuppressant administered post-surgery. Twenty patients were administered oral tacrolimus capsules in conjunction with 0.1 % tacrolimus eye drops, constituting the combination with systemic treatment group (group 1), while another twenty patients were solely administered 0.1 % tacrolimus eye drops, forming the topical treatment group (group 2). The occurrence of rejection, corneal neovascularization, corneal graft edema and visual acuity were documented in both groups. Results: In comparison to patients in group 2, patients in group 1 exhibited a significant reduction in rejection rate (p < 0.05). Additionally, the average time of neovascularization in group 1 was delayed and the number of cases was lower (p < 0.05). Furthermore, a smaller proportion of patients in group 1 experienced corneal graft edema (25 vs 60 %, p < 0.05), while a higher percentage of patients in group 1 demonstrated improved visual acuity (90 vs 60 %, p < 0.05). Conclusion: Concurrent administration of tacrolimus eye drops and capsules orally effectively mitigates anti-rejection reactions, regulation of neovascularization, management of graft edema and enhancement of visual acuity in high-risk keratoplasty patients when compared to the use of tacrolimus eye drops as a standalone treatment. These results have the potential to stimulate novel avenues of investigation in future clinical research.
- Subjects
CHINA; CORNEA surgery; INTRAOCULAR drug administration; TACROLIMUS; EYE drops; VISUAL acuity
- Publication
Tropical Journal of Pharmaceutical Research, 2024, Vol 23, Issue 1, p157
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v23i1.20