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- Title
Management of Patients With Muscle-Invasive and Metastatic Bladder Cancer.
- Authors
Henry, N. Lynn; Macvicar, Gary; Hussain, Maha
- Abstract
Bladder cancer is the fifth most common cancer diagnosed in the United States. Prognosis for this disease is dependent on both tumor stage and grade. Radical cystectomy has been the standard treatment for muscle-invasive local disease; however, combined-modality approaches with the use of chemotherapy are gaining momentum with data suggesting survival improvement. Patients with metastatic disease have poor long-term survival rates despite systemic multiagent chemotherapy. A variety of agents, including newer cytotoxic drugs and biologically targeted agents, are under investigation to determine the most effective regimen. The special needs of specific patient populations, such as the elderly, those with a suboptimal performance status, and patients with medical comorbidities have gained more attention. Progress in the treatment of this disease is dependent on supporting ongoing and future clinical trials.
- Subjects
UNITED States; BLADDER cancer; TUMOR markers; IMMUNOLOGICAL adjuvants; DRUG therapy; CLINICAL trials
- Publication
Oncology (08909091), 2005, Vol 19, Issue 10, p1333
- ISSN
0890-9091
- Publication type
Article