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- Title
TLR2 Is Necessary to Inflammatory Response in Coxiella burnetii Infection.
- Authors
MEGHARI, SORAYA; HONSTETTRE, AMÉLIE; LEPIDI, HUBERT; RYFFEL, BERNARDT; RAOULT, DIDIER; MEGE, JEAN‐LOUIS
- Abstract
The resolution of Q fever, a zoonosis caused by Coxiella burnetii, depends on efficient innate and adaptive immune responses. Such responses are influenced by Toll-like receptors (TLRs). TLR4 is involved only in part in immune responses against C. burnetii, suggesting a role for TLR2. We investigated C. burnetii infection in wild-type and TLR2-/- mice. C. burnetii organisms were similarly eliminated by wild-type and TLR2-/- mice. In contrast, the formation of granulomas, a marker for efficient cell-mediated immunity, was markedly impaired. These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance.
- Subjects
COXIELLA burnetii; Q fever; IMMUNE response; GRANULOMA; RICKETTSIAL diseases
- Publication
Annals of the New York Academy of Sciences, 2005, Vol 1063, Issue 1, p161
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1355.025