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- Title
Influence of Selenium on Hepatic Mitochondrial Antioxidant Capacity in Ducklings Intoxicated with Aflatoxin B.
- Authors
Shi, Dayou; Guo, Shining; Liao, Shenquan; Su, Rongsheng; Pan, Jiaqiang; Lin, Yuanchao; Tang, Zhaoxin
- Abstract
The aim of the study was to investigate the effect of selenium on hepatic mitochondrial antioxidant capacity in ducklings administrated with aflatoxin B (AFB). Ninety 7-day-old ducklings were randomly divided into three groups (groups I-III). Group I was used as a blank control. Group II was administered with AFB (0.1 mg/kg body weight). Group III was administered with AFB (0.1 mg/kg body weight) plus selenium (sodium selenite, 1 mg/kg body weight). All treatments were given once daily for 21 days. The results showed that the activities of mitochondrial superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and glutathione reductase (GR) in group II ducklings significantly decreased when compared with group I ( P < 0.01). Furthermore, the content of hepatic mitochondrial malondialdehyde (MDA) significantly increased ( P < 0.01). However, the activities of hepatic mitochondrial SOD, CAT, GSH-Px, and GR in group III ducklings significantly increased when compared with group II ( P < 0.05). In addition, the content of hepatic mitochondrial MDA significantly decreased ( P < 0.01). These results revealed that AFB significantly induced hepatic mitochondrial antioxidant dysfunction. However, sodium selenite could significantly ameliorate the negative effect induced by AFB.
- Subjects
SODIUM selenite; ANTIOXIDANTS; MITOCHONDRIAL DNA; MALONDIALDEHYDE; DUCKLINGS
- Publication
Biological Trace Element Research, 2012, Vol 145, Issue 3, p325
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-011-9201-z