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- Title
In Vivo Cellular Magnetic Imaging: Labeled versus Unlabeled Cells.
- Authors
Bulte, Jeff W. M.; Wang, Chao; Shakeri‐Zadeh, Ali
- Abstract
Superparamagnetic iron oxide (SPIO)‐labeling of cells has been applied for magnetic resonance imaging (MRI) cell tracking for over 30 years, having resulted in a dozen or so clinical trials. SPIO nanoparticles are biodegradable and can be broken down into elemental iron, and hence the tolerance of cells to magnetic labeling has been overall high. Over the years, however, single reports have accumulated demonstrating that the proliferation, migration, adhesion, and differentiation of magnetically labeled cells may differ from unlabeled cells, with inhibition of chondrocytic differentiation of labeled human mesenchymal stem cells (hMSCs) as a notable example. This historical perspective provides an overview of some of the drawbacks that can be encountered with magnetic labeling. Now that magnetic particle imaging (MPI) cell tracking is emerging as a new in vivo cellular imaging modality, there has been a renaissance in the formulation of SPIO nanoparticles this time optimized for MPI. Lessons learned from the occasional past pitfalls encountered with SPIO‐labeling of cells for MRI may expedite the possible future clinical translation of (combined) MRI/MPI cell tracking.
- Subjects
MAGNETIC particle imaging; CELL imaging; HUMAN stem cells; MAGNETIC resonance imaging; MESENCHYMAL stem cells; SUPERVISED learning
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 50, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202207626