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- Title
Physical nanochitin/microemulsion composite hydrogels for hydrophobic Nile Red release under in vitro physiological conditions.
- Authors
Wang, Zhiguo; Wang, Rong; Xu, Pengbo; Yu, Juan; Liu, Liang; Fan, Yimin
- Abstract
Abstract: A physical composite nanochitin/microemulsion (NCh/ME) hydrogel for a prolonged release of hydrophobic compounds (drugs) under in vitro physiological conditions was investigated. A strong physical hydrogel was prepared by an alkali gas phase coagulation bath composting NCh with an oil in water ME in which a hydrophobic dye, Nile Red (NR), was embedded to simulate a drug release process. Different release conditions, such as concentration of NCh, diameter of ME, temperature and specific surface areas, were studied. The results showed that the NCh/ME composite hydrogel effectively encapsulated NR with a prolonged release period of 60 h in phosphate-buffered saline (PBS pH 7.4, similar to physiological conditions), which demonstrated the significance of NCh/ME composite hydrogels for hydrophobic compound (drug) delivery.Graphical abstract:
- Subjects
HYDROGELS; HYDROPHOBIC compounds; GAS phase reactions; COAGULATION; DRUG delivery systems
- Publication
Cellulose, 2019, Vol 26, Issue 2, p1221
- ISSN
0969-0239
- Publication type
Article
- DOI
10.1007/s10570-018-2119-2