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- Title
Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach.
- Authors
Nölte, Ingo; Lütkhoff, Ann-Theres; Stuck, Boris A.; Lemmer, Björn; Schredl, Michael; Findeisen, Peter; Groden, Christoph
- Abstract
Purpose To correlate pineal parenchyma volume (PP) to circadian melatonin profiles and to determine the 24-hour melatonin per volume of pineal tissue (MLPV). Furthermore, we compared melatonin profiles of cystic and solid glands. Methods In 15 healthy male subjects (20-27 years) the PP was determined using high-resolution magnetic resonance imaging (trueFISP, isotropic voxel: 0.8 mm3). Melatonin plasma concentrations (MC) were determined every 2 hours for 24 hours. Results Mean PP was 125 ± 54 mm3. PP correlated linearly to maximum MC and to 24-hour melatonin ( r = 0.61 and r = 0.64, P < 0.05) but not to minimum MC. The 24-hour melatonin was 653 ± 242.6 pg/mL, MLPV was 5.8 ± 2.3 pg/mL*ml−1. Nine pineal glands were solid and six were cystic. PP of solid glands showed higher linear correlations to maximum melatonin, to 24-hour melatonin, and to the slope of the melatonin increase of the curve ( P < 0.05). Conclusion PP correlates linearly to melatonin plasma concentrations in humans. MLPV displays similar interindividual differences as 24-hour melatonin. PP of solid glands show better correlation to melatonin profiles than cystic. J. Magn. Reson. Imaging 2009. © 2009 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2009, Vol 30, Issue 3, p499
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.21872