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- Title
New Bicyclic Pyridine-Based Hybrids Linked to the 1,2,3-Triazole Unit: Synthesis via Click Reaction and Evaluation of Neurotropic Activity and Molecular Docking.
- Authors
Sirakanyan, Samvel N.; Spinelli, Domenico; Petrou, Anthi; Geronikaki, Athina; Kartsev, Victor G.; Hakobyan, Elmira K.; Yegoryan, Hasmik A.; Zuppiroli, Luca; Zuppiroli, Riccardo; Ayvazyan, Armen G.; Paronikyan, Ruzanna G.; Arakelyan, Tatevik A.; Hovakimyan, Anush A.
- Abstract
The synthesis of new original bicyclic pyridine-based hybrids linked to the 1,2,3-triazole unit was described via a click reaction. The anticonvulsant activity and some psychotropic properties of the new compounds were evaluated. The biological assays demonstrated that some of the studied compounds showed high anticonvulsant and psychotropic properties. The five most active compounds (7a, d, g, j, and m) contain a pyrano [3,4-c]pyridine cycle with a methyl group in the pyridine ring in their structures. Furthermore, molecular docking studies were performed, and their results are in agreement with experimental data.
- Subjects
MOLECULAR docking; BIOLOGICAL assay; METHYL groups; GROUP rings; PYRIDINE
- Publication
Molecules, 2023, Vol 28, Issue 3, p921
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28030921