We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recent Advances in Prodigiosin as a Bioactive Compound in Nanocomposite Applications.
- Authors
Araújo, Rafael G.; Zavala, Natalia Rodríguez; Castillo-Zacarías, Carlos; Barocio, Mario E.; Hidalgo-Vázquez, Enrique; Parra-Arroyo, Lizeth; Rodríguez-Hernández, Jesús Alfredo; Martínez-Prado, María Adriana; Sosa-Hernández, Juan Eduardo; Martínez-Ruiz, Manuel; Chen, Wei Ning; Barceló, Damià; Iqbal, Hafiz M.N.; Parra-Saldívar, Roberto
- Abstract
Bionanocomposites based on natural bioactive entities have gained importance due to their abundance; renewable and environmentally benign nature; and outstanding properties with applied perspective. Additionally, their formulation with biological molecules with antimicrobial, antioxidant, and anticancer activities has been produced nowadays. The present review details the state of the art and the importance of this pyrrolic compound produced by microorganisms, with interest towards Serratia marcescens, including production strategies at a laboratory level and scale-up to bioreactors. Promising results of its biological activity have been reported to date, and the advances and applications in bionanocomposites are the most recent strategy to potentiate and to obtain new carriers for the transport and controlled release of prodigiosin. Prodigiosin, a bioactive secondary metabolite, produced by Serratia marcescens, is an effective proapoptotic agent against bacterial and fungal strains as well as cancer cell lines. Furthermore, this molecule presents antioxidant activity, which makes it ideal for treating wounds and promoting the general improvement of the immune system. Likewise, some of the characteristics of prodigiosin, such as hydrophobicity, limit its use for medical and biotechnological applications; however, this can be overcome by using it as a component of a bionanocomposite. This review focuses on the chemistry and the structure of the bionanocomposites currently developed using biorenewable resources. Moreover, the work illuminates recent developments in pyrrole-based bionanocomposites, with special insight to its application in the medical area.
- Subjects
PRODIGIOSIN; SERRATIA marcescens; BIOACTIVE compounds; BIOMOLECULES; NANOCOMPOSITE materials
- Publication
Molecules, 2022, Vol 27, Issue 15, p4982
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27154982