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- Title
The Lipidome Fingerprint of Longevity.
- Authors
Jové, Mariona; Mota-Martorell, Natàlia; Pradas, Irene; Galo-Licona, José Daniel; Martín-Gari, Meritxell; Obis, Èlia; Sol, Joaquim; Pamplona, Reinald; Plastina, Pierluigi
- Abstract
Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species—humans included—demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.
- Subjects
LONGEVITY; ANIMAL longevity; COMPARATIVE genetics; ANIMAL species; CELL membranes; FATTY acids
- Publication
Molecules, 2020, Vol 25, Issue 18, p4343
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25184343