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- Title
Electrochemical Detecting Lung Cancer-Associated Antigen Based on Graphene-Gold Nanocomposite.
- Authors
Zheng Wei; Junping Zhang; Aihua Zhang; Yanchun Wang; Xiaoping Cai
- Abstract
Using a Au nanoparticle/reduced graphene oxide composite (AuNP-RGO), a signal-enhanced electrochemical immunosensor without label was created to detect neuron-specific enolase (NSE). Furthermore, an environmentally-friendly method was developed to prepare AuNP-RGO by employing chitosan (CS), which served as reducing and stabilizing agent. We showed that the sensitivity of the immunosensor designed in this report was remarkably enhanced because of the numerous active sites in the sensor provided by the AuNP-RGO nanostructure. For the quantification of NSE, the immunosensor exhibited a positive linear relationship with the concentration in the range of 0.1 to 2000 ng/mL, where the limit of the detection was 0.05 ng/mL.
- Subjects
GOLD nanoparticles; ENOLASE; ELECTROCHEMICAL sensors; GRAPHENE oxide; CHITOSAN
- Publication
Molecules, 2017, Vol 22, Issue 3, p392
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22030392