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- Title
The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity and Cardiovascular Disease.
- Authors
Srikanthan, Krithika; Shapiro, Joseph I.; Sodhi, Komal
- Abstract
Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
- Subjects
ADENOSINE triphosphatase; IONS; PROTEINS; CARDIOTONIC agents; STEROIDS
- Publication
Molecules, 2016, Vol 21, Issue 9, p1172
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules21091172