We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Recombination drives the emergence of orf virus diversity: evidence from the first complete genome sequence of an Indian orf virus isolate and comparative genomic analysis.
- Authors
Sahu, Basanta Pravas; Majee, Prativa; Singh, Ravi Raj; Sahoo, Niranjana; Nayak, Debasis
- Abstract
Contagious pustular dermatitis is a disease that primarily infects small ruminants and possesses zoonotic potential. It is caused by orf virus (ORFV), a member of the genus Parapoxvirus. In this study, we evaluated an ORFV outbreak in goats in Madhya Pradesh, a state in central India, during 2017. The transboundary potential of this virus was evaluated by constructing phylogenetic trees. The complete genome sequence of an ORFV isolate named Ind/MP/17 was found to be 139,807 bp in length with 63.7% GC content and 132 open reading frames (ORFs) flanked by 3,910-bp inverted terminal repeats (ITRs). An investigation into evolutionary parameters such as selection pressure (θ = dN/dS) and nucleotide diversity (π) demonstrated that ORFV has undergone purifying selection. A total of 40 recombination events were identified, 21 of which were evident in the Ind/MP/17 genome, indicating its ability to generate new variants.
- Subjects
MADHYA Pradesh (India); INDIA; WHOLE genome sequencing; VIRUS diversity; GENOMICS; COMPARATIVE genomics; COMPARATIVE studies
- Publication
Archives of Virology, 2022, Vol 167, Issue 7, p1571
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-022-05443-5