We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of Modified Forms of Sodium Humate PowHumus on the Balance of Arginine in Peritoneal Macrophages of Intact Mice.
- Authors
Trofimova, E. S.; Zykova, M. V.; Danilets, M. G.; Ligacheva, A. A.; Sherstoboev, E. Yu.; Selivanova, N. S.; Azarkina, L. A.; Zhirkova, A. M.; Zhang, Yu.; Perminova, I. V.; Zhdanov, V. V.; Belousov, M. V.
- Abstract
Substances of silver nanoparticles dialyzed through a 13 kDa membrane, synthesized in a medium of humic ligands modified with hydroquinone and 2-hydroxynaphthoquinone from PowHumus brown coal, specifically enhance the M2 properties of peritoneal macrophages due to inhibition of NO synthase and significant activation of arginase, thus enhancing anti-inflammatory properties of cells. In small, but effective concentrations, they do not have cytotoxic properties and do not contain pyrogenic impurities. The studied humates are able to influence the mechanisms of immune response formation and are an effective means for correcting inflammation and regeneration.
- Subjects
PERITONEAL macrophages; HUMATES; NITRIC-oxide synthases; LIGNITE; SILVER nanoparticles; ARGININE
- Publication
Bulletin of Experimental Biology & Medicine, 2024, Vol 177, Issue 1, p68
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-024-06133-9