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- Title
Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes.
- Authors
Ivanov, S. V.; Ostrovskaya, R. U.; Sorokina, A. V.; Seredenin, S. B.
- Abstract
Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals. A correlation between morphometric data and blood glucose level was revealed. A possible role of σ1-receptors in the cytoprotective effects of Afobazole in respect to pancreatic β cells is discussed.
- Subjects
ANIMAL models of diabetes; TYPE 2 diabetes; STREPTOZOTOCIN; BLOOD sugar; CYTOPROTECTION
- Publication
Bulletin of Experimental Biology & Medicine, 2020, Vol 169, Issue 6, p783
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-020-04978-4