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- Title
Aminoethane Sulfonic Acid Magnesium Salt Inhibits Ca<sup>2+</sup> Entry Through NMDA Receptor Ion Channel In Vitro.
- Authors
Turovsky, E. A.; Blinova, E. V.; Semeleva, E. V.; Zinchenko, V. P.; Astashev, M. E.; Blinov, D. S.; Skachilova, S. Ya.; Geras'kina, M. M.; Lebedev, A. B.; Gromova, I. A.
- Abstract
The effect of a cerebroprotective agent magnesium bis-aminoethanesulfonate (laboratory code FS-LKhT-317) on intracellular calcium concentration was studied by the fluorescent imaging technique on neuroglial cell culture from Spraque-Dawley rat hippocampus. The substance produced a pronounced inhibitory effect and suppressed NMDA receptor activity in concentrations of ≥50 μM. The observed effects were reversible or partially reversible and were detected by a decrease in Ca2+ signal amplitude in neurons in response to NMDA applications in a Mg2+-free medium and by inhibition of Ca2+ pulses in magnesium-free medium (elimination of magnesium block).
- Subjects
GLUTAMIC acid; CELL membranes; ION channels; METHYL aspartate receptors; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 166, Issue 1, p39
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4284-6