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- Title
Role of Innate Immunity in Pregnant Patients with Vulvovaginal Infections in the Development of Intrauterine Infection in the Newborn.
- Authors
Tyutyunnik, V.; Kan, N.; Lomova, N.; Karapetyan, T.; Kogan, E.; Shchyogolev, A.
- Abstract
A total of 115 pregnant women were examined: 59 patients with opportunistic vulvovaginal infections and 56 without infection. Congenital immunity parameters (TLR-2, NF-κB, and IL-2 receptors in placental tissue) were studied by immunohistochemical methods. Realization of congenital infection was associated with activation of IL-6 receptors and TLR-2 in the placenta and an increase of NF-κB level. These changes seemed to reflect the strained status of congenital immunity and were responsible for the intensity of local inflammatory response.
- Subjects
VAGINAL diseases; IMMUNITY; PREGNANCY complications; NEONATAL diseases; IMMUNOHISTOCHEMISTRY; PLACENTA
- Publication
Bulletin of Experimental Biology & Medicine, 2014, Vol 158, Issue 1, p74
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-014-2695-6