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- Title
Pancreatic Fat Necrosis and Hemorrhagic Necrosis as Separate Morphological and Functional Entities.
- Authors
Bakarev, M.; Vasilev, A.; Protsenko, S.
- Abstract
Peculiarities of pathomorphogenesis of two destructive forms of acute pancreatitis were compared using three experimental models. We have shown that the direction of the pathological process is determined by specifi c combinations of pathogenic factors. Pathological processes caused by common bile duct ligation (ductal hypertension) alone and in combination with injection of phospholipase A2 are characterized by mixed pattern with strong predominance of fat necrosis symptoms (coagulative acinar necrosis, infl ammatory demarcation, and sites of lipolysis) and hemorrhagic necrosis, respectively. Trypsin injection into the pancreatic tissue induces rapidly progressing hemorrhagic pancreatic necrosis with massive hemorrhages, extensive acinar necrosis, and weak cell reaction. Considerable differences in pathomorphogenesis and outcome of the pathological process allow us to consider pancreatic fat necrosis and hemorrhagic necrosis as separate morphological and functional entities, which is essential for the prognosis and treatment strategy.
- Subjects
FAT necrosis; PANCREATITIS; PANCREATIC diseases; HEMORRHAGIC diseases; BILE duct surgery; PHOSPHOLIPASE A2; TRYPSIN
- Publication
Bulletin of Experimental Biology & Medicine, 2013, Vol 154, Issue 6, p805
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-013-2061-0