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- Title
Use of Diabetes Technologies and Retinopathy in Adults With Type 1 Diabetes.
- Authors
Liu, T. Y. Alvin; Shpigel, Julia; Khan, Fatima; Smith, Kerry; Prichett, Laura; Channa, Roomasa; Kanbour, Sarah; Jones, Marissa; Abusamaan, Mohammed S.; Sidhaye, Aniket; Mathioudakis, Nestoras; Wolf, Risa M.
- Abstract
Key Points: Question: Are continuous glucose monitoring (CGM) and insulin pump use associated with the development of diabetic retinopathy (DR)? Findings: In this cohort study including 550 individuals with type 1 diabetes, CGM use was associated with lower odds of developing DR and proliferative DR. During the 8-year study period, in the age of diabetes technology, 21.8% of adults with type 1 diabetes in this cohort experienced progression of DR. Meaning: The findings of this study suggest that CGM should be encouraged for diabetes management, as it is associated with lower odds of developing DR. Importance: Diabetic retinopathy (DR) is a complication of diabetes that can lead to vision loss. Outcomes of continuous glucose monitoring (CGM) and insulin pump use in DR are not well understood. Objective: To assess the use of CGM, insulin pump, or both, and DR and proliferative diabetic retinopathy (PDR) in adults with type 1 diabetes (T1D). Design, Setting, and Participants: A retrospective cohort study of adults with T1D in a tertiary diabetes center and ophthalmology center was conducted from 2013 to 2021, with data analysis performed from June 2022 to April 2023. Exposure: Use of diabetes technologies, including insulin pump, CGM, and both CGM and insulin pump. Main Outcomes and Measures: The primary outcome was development of DR or PDR. A secondary outcome was the progression of DR for patients in the longitudinal cohort. Multivariable logistic regression models assessed for development of DR and PDR and association with CGM and insulin pump use. Results: A total of 550 adults with T1D were included (median age, 40 [IQR, 28-54] years; 54.4% female; 24.5% Black or African American; and 68.4% White), with a median duration of diabetes of 20 (IQR, 10-30) years, and median hemoglobin A1c (HbA1c) of 7.8% (IQR, 7.0%-8.9%). Overall, 62.7% patients used CGM, 58.2% used an insulin pump, and 47.5% used both; 44% (244 of 550) of the participants had DR at any point during the study. On univariate analysis, CGM use was associated with lower odds of DR and PDR, and CGM with pump was associated with lower odds of PDR (all P <.05), compared with no CGM use. Multivariable logistic regression adjusting for age, sex, race and ethnicity, diabetes duration, microvascular and macrovascular complications, insurance type, and mean HbA1c, showed that CGM was associated with lower odds of DR (odds ratio [OR], 0.52; 95% CI, 0.32-0.84; P =.008) and PDR (OR, 0.42; 95% CI, 0.23-0.75; P =.004), compared with no CGM use. In the longitudinal analysis of participants without baseline PDR, 79 of 363 patients (21.8%) had progression of DR during the study. Conclusions and Relevance: In this cohort study of adults with T1D, CGM use was associated with lower odds of developing DR and PDR, even after adjusting for HbA1c. These findings suggest that CGM may be useful for diabetes management to mitigate risk for DR and PDR. This cohort study examines the association of use of continuous glucose monitoring and insulin pumps with diabetic retinopathy among patients with type 1 diabetes.
- Subjects
MARYLAND; TYPE 1 diabetes; RISK assessment; PEARSON correlation (Statistics); DISEASE duration; GLYCOSYLATED hemoglobin; DATA analysis; DIABETIC retinopathy; LOGISTIC regression analysis; KRUSKAL-Wallis Test; DISEASE management; INSULIN pumps; SEVERITY of illness index; RETROSPECTIVE studies; TERTIARY care; DESCRIPTIVE statistics; MANN Whitney U Test; CHI-squared test; LONGITUDINAL method; ODDS ratio; CONTINUOUS glucose monitoring; STATISTICS; ELECTRONIC health records; CONFIDENCE intervals; DATA analysis software; DISEASE progression; DISEASE risk factors; DISEASE complications; ADULTS; MIDDLE age
- Publication
JAMA Network Open, 2024, Vol 7, Issue 3, pe240728
- ISSN
2574-3805
- Publication type
Article
- DOI
10.1001/jamanetworkopen.2024.0728