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- Title
Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease.
- Authors
Ichiro Mizushima; Kazunori Yamada; Kenichi Harada; Shoko Matsui; Takako Saeki; Satoru Kondo; Masayuki Takahira; Yuko Waseda; Yasuhito Hamaguchi; Hiroshi Fujii; Masakazu Yamagishi; Mitsuhiro Kawano
- Abstract
Objectives: This study aimed to investigate the diagnostic sensitivity of the cutoff values of IgG4- positive plasma cell (PC) number and IgG4-positive/CD138-positive cell ratio proposed by the International consensus statement (ICS) on the pathology of IgG4-related disease (IgG4-RD) in typical multiple lesions of patients with IgG4-RD. Methods: We evaluated IgG4-positive PC number and IgG4-positive/CD138-positive cell ratio in 39 samples from 18 IgG4-RD patients having more than two typical lesions of IgG4-RD. Results: We evaluated 12 submandibular, 12 ophthalmic, six skin, five kidney, two pancreatic, and one bronchus and prostate lesion each in 18 patients with typical clinical, serological, and radiographic features. Concerning IgG4þPC number per high-power field, most ophthalmic (11/12), kidney (5/5), pancreatic (2/2), and bronchial lesions (1/1) fulfilled the cutoff value of ICS, whereas many of the submandibular (6/12) and skin lesions (0/6) did not. In contrast to the absolute number, all lesions fulfilled the cutoff value of IgG4þ/CD138þcell ratio. In eight cases, only one or two lesions in the same patient fulfilled the cutoff value of ICS, while the others did not. Conclusions: These results suggest that ICS criteria have different sensitivities among the affected organs for the diagnosis of IgG4-RD.
- Subjects
IMMUNOGLOBULIN G; SEROLOGY; PLASMA cell diseases; BRONCHIAL diseases; PANCREATIC diseases
- Publication
Modern Rheumatology, 2018, Vol 28, Issue 2, p293
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1080/14397595.2017.1332540